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Communication Dans Un Congrès Année : 2022

Multiscale delivery platform based on natural bioactive compounds: a promising strategy towards skin healthcare

Résumé

The Global Burden of Disease project has shown that skin pathologies can have an impact on the well-being and social life of the patients [1]. Skin is submitted to numerous biological and physio-pathological situations where the prooxidant-antioxidant balance must be well controlled. An excess of reactive oxygen species (ROS) can lead to inflammatory processes and disrupt skin health. In this regard, natural bioactive compounds (NBC) with antioxidant and anti-inflammatory properties can contribute to recover normal dermal conditions. Among other NBC, curcumin possesses the capacity to efficiently act onto the skin by controlling the toxicity of ROS and through the activation of cytoprotective signaling pathways in dermal cells [2]. In a general way, due to their physico-chemical properties, formulation of NBC remains a challenge. Delivery systems are strategies that provide the required drug protection environment, allow to increase pay-loading of the active ingredients and preserve their action until their controlled release into the site of action. Our research strategy is based on the design, development and evaluation of the following multiscale delivery platform : a hydrogel matrix containing a NBC-loaded nanoparticulated reservoir, in order to explore its potential for topical dermal uses. We will present here some of our results concerning (i) the production of stable curcumin-loaded lipid nanocarriers, (ii) the preservation of their antioxidant properties and (iii) their cell biocompatibility. Curcumin-loaded lipid nanocarriers were successfully introduced into a carbopol hydrogel and rheological analysis revealed that the mechanical properties of the gel were not disturbed. Overall, these results demonstrate the feasibility of combining a NBC with antioxidant properties, the use of lipid nanocarriers and a hydrogel support into a skin-healthcare multiscale platform. [1] Flohr C, Hay R. Putting the burden of skin diseases on the global map. Br J Dermatol 2021;184(2):189-90. [2] Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007;595:105-25.
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Dates et versions

hal-04449193 , version 1 (09-02-2024)

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  • HAL Id : hal-04449193 , version 1

Citer

Violeta Rodriguez-Ruiz, Rosa Calderon-Jacinto, Pietro Matricardi, Virginie Gueguen, Graciela Pavon-Djavid, et al.. Multiscale delivery platform based on natural bioactive compounds: a promising strategy towards skin healthcare. Cosmetic Measurement and Testing (COMET 4th Edition), Cosmetic Valley, Jul 2022, Cergy- Pontoise, France. ⟨hal-04449193⟩
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