Formulation of a multiscale fluid gel based on nanostructure lipid carriers (NLCs) for wound-healing applications. - CY Cergy Paris Université Accéder directement au contenu
Communication Dans Un Congrès Année : 2019

Formulation of a multiscale fluid gel based on nanostructure lipid carriers (NLCs) for wound-healing applications.

Résumé

Skin’s regeneration emerges as a main challenge for both medicine and cosmetics. Cosmeceutics can be defined as cosmetics in which the active ingredient has a proven therapeutic effect. In this context, the aim of this work is to formulate a fluid gel being able to mediate interesting tissue responses, promote the delivery of an active ingredient and be easily applied on the skin. (Fig. 1). Natural active ingredients presenting antioxidant, anti-inflammatory and/or antibacterial properties such as curcumin or astaxanthin can be included in such formulation by firstly being entrapped in a special type of nanoparticles: nanostructured lipid carriers (NLCs)[1]. This innovative multiscale formulation will be able to protect the active ingredient, and thus, foster it’s wound healing effects. In this study we focused on the preparation and characterization of the major components of the formulation. First, the synthesis and characterization of the unloaded and active ingredient-loaded NLCs. Then, the incorporation of the NLC into a carbomer gel and the study of the mechanical properties of the whole system. Negatively charged nanoparticles of an average size of about 250 nm and a polydispersity value of 0.3 were obtained by a reproducible process. Their physicochemical properties were characterized by means of dynamic light scattering (DLS), atomic force microscopy (AFM), X-ray diffraction (XRD) among others. Mechanical properties of the gel itself and the gel containing NLCs were studied by rheology. Our results show that NLCs remained stable for at least 2 months and that their introduction into the fluid gel matrix did not affect the mechanical properties of the gel. References: [1] V. Rodriguez-Ruiz et al., Molecules (2018) 104 : 10-18, doi: 10.3390/molecules23102601
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Dates et versions

hal-04449114 , version 1 (09-02-2024)

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  • HAL Id : hal-04449114 , version 1

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Rosa Calderon-Jacinto, Danisa Lopez, Marianna Gentilli, Sandrine Abraham, Serena Sandhu, et al.. Formulation of a multiscale fluid gel based on nanostructure lipid carriers (NLCs) for wound-healing applications.. 3rd BIOMAT-Materials for Health Congress, BIOMAT-MatSan, Jun 2019, La Grande Motte, France. ⟨hal-04449114⟩
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